Xi'an TOPTION Instrument Co., Ltd. is one of the most reliable manufacturers and suppliers of molecular distillation pharmaceutical machine in China. We provide high quality solutions & products for global customers who work in chemistry, biology, pharmaceutical, food, etc. If you have any enquiry about lab solution customization, please feel free to email us.
Description
TOPTION's molecular distillation systems are specifically engineered to meet the stringent demands of modern pharmaceuticals. The technology leverages the principle of high vacuum distillation, operating at extremely low pressures to significantly lower boiling points. This allows the evaporation of heat-sensitive materials at temperatures far below their conventional boiling points, effectively preventing thermal degradation while achieving highly efficient separation.
Molecular Distillation System Components
Our Distillation Apparatus is comprised of several core components that work together precisely to ensure superior performance.
Feed System: Precision and Stability
Our feed system employs high-precision metering pumps to maintain a consistent and reliable flow of material into the evaporator. This is critical for ensuring stable working conditions and maximizing separation efficiency. The system can handle a wide range of materials, including low-viscosity liquids and high-viscosity slurries.
Distillation Section: Wipers, Heating, and Condenser
The key component of the distillation system is the wiping film evaporator. Our extremely effective wiping method produces a consistent, thin liquid coating over the heated surface, increasing evaporation area while decreasing residence time. The internal condenser is located exceptionally close to the heated surface, ensuring that molecules evaporate and immediately condensate as the Light Fraction/Distillate, resulting in highly effective separation.
Vacuum System: Creating Extremely Low Pressure
TOPTION's high vacuum distillation system uses high-performance vacuum pumps and accuracy gauges to maintain ultra-low pressures (0.01 Pa).
Collection Systems: Multi-Stage Separation
We provide multi-stage collection systems that can separate both the light fraction/distillate and the heavy fraction/residue/bottoms. For further refined separation, we may supply bespoke multi-stage solutions for the successful fractionation of high-boiling-point compounds.
Advantages
By choosing TOPTION, you are choosing not just a piece of equipment but a reliable partner dedicated to innovation in the pharmaceutical industry.
Short Material Heating Time
Low Evaporation Temperature
Self-Cleaning Heating Surface
High Evaporation Efficiency, Strong Adaptability, And Easy Operation
Case Studies and Applications
TOPTION's molecular distillation equipment has been successfully applied in numerous pharmaceutical companies globally.
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API
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Natural Extracts and Oils
Customizable Technical Specifications
Material Customization:
Select the optimal construction material based on your process requirements, product characteristics, and operating environment.
Stainless Steel (304 / 316L / 904L / HC276) - Excellent corrosion resistance, high temperature tolerance; ideal for industrial applications.
High Borosilicate Glass - Crystal-clear visibility for process observation, perfect for laboratory research and teaching.
PTFE (Polytetrafluoroethylene) Seals - Superior airtightness and chemical resistance, ideal for high-vacuum environments.
Evaporation Surface Area & Processing Capacity：
Custom evaporation area from 0.1m² to 20m²
Processing capacity from 10L/H up to 2000L/H
Adjustable column inner diameters (60mm to 500mm) and condenser surface area to match your throughput requirements.
Feed & Discharge Options
Feeding methods: Glass needle valve or gear pump; supports both continuous and batch operations.
Discharge methods: Receiving flasks, intermediate buffer tanks, and gear pump continuous discharge. An optional one-way valve for changing collection bottles under vacuum without breaking the system pressure.
Film Formation Technology
Wiped Film - Best for high-viscosity materials, prevents material build-up.
Roller Film - Ensures uniform film thickness, suitable for heat-sensitive and volatile compounds.
Centrifugal + Secondary Mechanical Film - Maximizes separation efficiency, prevents uneven feed distribution.
Temperature Control & Vacuum Systems
Independent temperature control zones for evaporator, heavy component receiver, and light component condenser (ambient to 300°C).
Vacuum options: Standard rotary vane pump (0.1 Pa), optional diffusion pump or molecular pump (up to 0.01 Pa ultimate vacuum).
Automation & Control
PLC-based control system with real-time monitoring of rotational speed (0–450 RPM), temperature, and vacuum level.
Automated feeding and collection to reduce labor and human error.
An optional centralized control room for remote operation.
Special Customization Options
Cold Trap Design: Glass or stainless steel with viewing window.
Explosion-Proof Configuration: CNEX and ATEX certified for handling flammable/explosive materials.
Multi-Stage Distillation: Series connection to achieve ultra-high purity separation.
Certificate
About us
FAQ
Q: What makes TOPTION's system ideal for pharmaceuticals?
A: Our system is designed specifically for the strict standards of the pharmaceutical industry, offering GMP compatibility, precise control, and high customizability. It's high vacuum distillation technology gently handles heat-sensitive materials, ensuring product purity and activity.
Q: Can your system handle different batch sizes?
A: Yes. We offer a full range of equipment from lab to industrial scale. Whether you need to conduct small-batch R&D or large-scale production, we have a suitable molecular still solution for you.
Q: What kind of maintenance is required for the equipment?
A: Our equipment is designed to be robust and durable, with relatively simple daily maintenance, which mainly includes regularly changing vacuum pump oil, checking seals, and cleaning the evaporator surface. We provide detailed operation manuals and after-sales support to ensure long-term stable operation.
Q: How do you ensure product purity and prevent cross-contamination?
A: Our equipment features a modular design that is easy to disassemble and clean. Additionally, the system uses high-quality seals and pipelines and can be provided with separate collection systems upon request, fundamentally preventing cross-contamination between different product batches.
Molecular Distillation Video Content
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